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Temporal lobe uptake was assessed both qualitatively and quantitatively. Demographic and clinicopathological characteristics and voxel\u2010level uptake using SPM12 were compared between FTP\u2010positive and FTP\u2010negative cases. Intra\u2010reader reproducibility was evaluated with Krippendorff's alpha.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Minimal\/mild and moderate FTP uptake was seen in 32% of PART cases and 62% of controls, primarily in the left inferior temporal lobe. No demographic or clinicopathological differences were found between FTP\u2010positive and FTP\u2010negative cases. High intra\u2010reader reproducibility (\u03b1\u00a0=\u00a00.83) was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>FTP PET imaging did not show a specific uptake pattern for PART diagnosis, indicating that in vivo PART identification using FTP PET is challenging. Similar uptake in controls suggests non\u2010specific uptake in PART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:sup>18<\/jats:sup>F\u2010flortaucipir (FTP) PET scans were analyzed for diagnosing PART antemortem.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>32% of PART cases had minimal\/mild FTP uptake in the left inferior temporal lobe.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Similar to PART FTP uptake was found in 62% of control subjects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>No specific uptake pattern was found, challenging in vivo PART diagnosis.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14301","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:00:30Z","timestamp":1729148430000},"page":"8605-8614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the feasibility of <sup>18<\/sup>F\u2010flortaucipir PET imaging in the antemortem diagnosis of primary age\u2010related tauopathy (PART): An observational imaging\u2010pathological study"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7521-7082","authenticated-orcid":false,"given":"Anna","family":"Lavrova","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo 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