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However, few studies have examined how these features relate to AD biomarkers in cognitively unimpaired (CU) older adults.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Meta\u2010analyses were performed using cross\u2010sectional data from nine cohorts (\n n<\/jats:italic>\n \u00a0=\u00a07219, mean age (SD): 71.17 (5.9), 56.5% female) to determine associations of SCD\u2010\n plus<\/jats:italic>\n features with positron emission tomography (PET)\u2013 or cerebrospinal fluid (CSF)\u2013derived amyloid beta (A\u03b2) and tau biomarkers.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Participants with preclinical AD (community\u2010based only) were more likely to fulfill SCD\u2010\n plus<\/jats:italic>\n features. The presence of self\u2010reported memory decline, associated concern\/worry, and a higher number of fulfilled features were all associated with high A\u03b2 levels. Only the latter was associated with abnormal tau.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n Simultaneous endorsement of multiple SCD\u2010\n plus<\/jats:italic>\n features is a robust indicator of abnormal AD biomarkers in CU older adults, whereas isolated SCD features seem only sensitive to elevated A\u03b2, supporting their value as early behavioral markers of preclinical AD.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n About two\u2010tenths of our sample had abnormal amyloid beta (A\u03b2) levels with evidence of subjective cognitive decline (SCD).<\/jats:p>\n <\/jats:list-item>\n \n \n Preclinical AD subsamples (community\u2010based) had a higher percentage of participants meeting SCD\u2010\n plus<\/jats:italic>\n features. Self\u2010reported memory decline and concern\/worry were the sole features associated with high A\u03b2, but not tau, burden.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A higher number of fulfilled SCD\u2010\n plus<\/jats:italic>\n features are linked to high A\u03b2 and tau burden.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Use of multiple SCD\u2010\n plus<\/jats:italic>\n features may help identify early stages of biological AD.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14307","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T07:39:02Z","timestamp":1740209942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["SCD\u2010\n plus<\/i>\n features and AD biomarkers in cognitively unimpaired samples: A meta\u2010analytic approach for nine cohort studies"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-1155","authenticated-orcid":false,"given":"Elizabeth","family":"Kuhn","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Bonn Bonn Germany"},{"name":"Department of Cognitive Disorders and Old Age Psychiatry University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5633-2954","authenticated-orcid":false,"given":"Hannah M.","family":"Klinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Amariglio","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Center for Alzheimer Research and Treatment (CART) Brigham & Women's 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Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University Universit\u00e4tsplatz 2 Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Heneka","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Belvaux Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-7932","authenticated-orcid":false,"given":"Gael","family":"Ch\u00e9telat","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 Physiopathology and Imaging of Neurological Disorders (PhIND) Neuropresage Team, Cyceron Caen cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorene M.","family":"Rentz","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Boston 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M.","family":"Sikkes","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration Amsterdam The Netherlands"},{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte E.","family":"Teunnissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory Department of Laboratory Medicine Amsterdam Neuroscience, Amsterdam University Medical Center Vrije Universiteit Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-8724","authenticated-orcid":false,"given":"Argonde C.","family":"Van Harten","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-4233","authenticated-orcid":false,"given":"Elsmarieke M.","family":"Van De Giessen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Center Vrije Universiteit Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-1921","authenticated-orcid":false,"given":"Lorena","family":"Rami","sequence":"additional","affiliation":[{"name":"Hospital Clinic. 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