{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:48:49Z","timestamp":1792590529794,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG072559"],"award-info":[{"award-number":["R01AG072559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of social activity to average age at dementia onset.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n In the Rush Memory and Aging Project (MAP), we followed 1923 dementia\u2010free older adults and conducted annual clinical evaluations of dementia\/mild cognitive impairment (MCI).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n During a mean follow\u2010up of 6.7 (SD\u00a0=\u00a04.7) years, 545 participants developed dementia, and 695 developed MCI. Using Accelerated Failure Time models adjusted for age, sex, education, race\/ethnicity, and marital status, we found predicted mean age of dementia onset for the least socially active was 87.7 years, approximately 5 years earlier than the most socially active (mean age\u00a0=\u00a092.2,\n p<\/jats:italic>\n <\u00a0.01); we found a similar 5\u2010year difference in age at MCI onset by social activity.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Our findings highlight the value of social activity as a possible community\u2010level intervention for reducing dementia.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Accelerated failure time models estimated age at dementia onset by social activity level to aid interpretation.<\/jats:p>\n <\/jats:list-item>\n \n Higher social activity was associated with a 5\u2010year older age at dementia onset.<\/jats:p>\n <\/jats:list-item>\n \n Economic research shows a 5\u2010year delay translates to US$500,000 of healthcare savings per capita.<\/jats:p>\n <\/jats:list-item>\n \n Our findings help understand the public health significance of social activity.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14316","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T07:01:06Z","timestamp":1735282866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Late\u2010life social activity and subsequent risk of dementia and mild cognitive impairment"],"prefix":"10.1002","volume":"21","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Grodstein","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Internal Medicine Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana W.","family":"Capuano","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"James","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center, Rush University Medical Center Chicago Illinois USA"},{"name":"Department of Internal Medicine Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"PattersonC.World Alzheimer report 2018.The State of the Art of Dementia Research: New Frontiers(2018)."},{"key":"e_1_2_8_3_1","article-title":"Global and regional spending on dementia care from 2000\u20102019 and expected future health spending scenarios from 2020\u20102050: an economic modelling exercise","volume":"45","author":"Velandia PP","year":"2022","journal-title":"E Clin 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