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measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo\u2010inositol.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Both plasma p\u2010tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR\u2010derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo\u2010inositol, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This study leverages high\u2010resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Tau phosphorylated at threonine 181 (p\u2010tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>p\u2010tau181 and GFAP are robust in reflecting 7T MR\u2010based changes in AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The strongest associations were for frontal\/parietal MR changes and MRS neuroinflammation.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14318","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T04:19:55Z","timestamp":1731989995000},"page":"8684-8699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Plasma p\u2010tau181 and GFAP reflect 7T MR\u2010derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and 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