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ADNI has been instrumental in standardizing and validating amyloid beta (A\u03b2) and tau positron emission tomography (PET) imaging. ADNI data were used for the US Food and Drug Administration (FDA) approval of the Fujirebio and Roche Elecsys cerebrospinal fluid diagnostic tests. Additionally, ADNI provided data for the trials of the FDA\u2010approved treatments aducanumab, lecanemab, and donanemab.<\/jats:p>\n More than 6000 scientific papers have been published using ADNI data, reflecting ADNI's promotion of open science and data sharing. Despite its enormous success, ADNI has some limitations, particularly in generalizing its data and findings to the entire US\/Canadian population. This introduction provides a historical overview of ADNI and highlights its significant accomplishments and future vision to pioneer \u201cthe clinical trial of the future\u201d focusing on demographic inclusivity.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n The Alzheimer's Disease Neuroimaging Initiative (ADNI) introduced a novel model for public\u2010private partnerships and data sharing.<\/jats:p>\n <\/jats:list-item>\n \n It successfully validated amyloid and Tau PET imaging, as well as CSF and plasma biomarkers, for diagnosing Alzheimer's disease.<\/jats:p>\n <\/jats:list-item>\n \n ADNI generated and disseminated vital data for designing AD clinical trials.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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