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We selected 352 clinically normal older participants with up to 9 years of PiB\u2010PET and PACC\u20105 data from the Harvard Aging Brain Study (HABS).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A\u03b2 accumulation was associated with subsequent cognitive decline beyond the effects of cross\u2010sectional A\u03b2 burden. Within this model including covariates such as age, sex, and apolipoprotein \u03b54 (<jats:italic>APOE<\/jats:italic>\u03b54) status, we found no evidence supporting previously published associations between cross\u2010sectional tau\u2010PET and cognitive intercept\/slope.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Short\u2010term A\u03b2 changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross\u2010sectional A\u03b2 and MTL tau.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>A\u03b2 accumulation is associated with subsequent cognitive decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>High A\u03b2 burden is not the sole metric signaling impending cognitive decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Contrary to prior work, MTL tau\u2010PET and cognition were not associated in our models.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Models of bivariate latent A\u03b2 and cognitive change may eclipse the\u00a0effects of MTL tau.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14326","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T08:36:56Z","timestamp":1730191016000},"page":"8728-8738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Latent change\u2010on\u2010change between amyloid accumulation and cognitive decline"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5633-2954","authenticated-orcid":false,"given":"Hannah M.","family":"Klinger","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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