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Network analysis identified two modules related to pathways including a natural killer (NK) cell\u2013mediated immunity. Machine learning analysis showed the classification of A\u03b2 positivity improved with the inclusion of gene expression data.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our results in a Korean population suggest A\u03b2 deposition\u2010associated genes are enriched in NK cell\u2013mediated immunity, providing a better understanding of AD molecular mechanisms and yielding potential diagnostic and therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Dysregulated genes were associated with amyloid beta (A\u03b2) deposition on positron emission tomography in a Korean cohort.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dysregulated genes in Alzheimer's disease were replicated in an independent Korean cohort.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Gene network modules\u00a0were associated with A\u03b2 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