{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:37:37Z","timestamp":1785317857676,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003136","name":"Edmond J. 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The area density of phosphorylated tau (p\u2010tau), amyloid beta (A\u03b2), \u03b1\u2010synuclein, and phosphorylated TDP\u201043 protein deposits together with pyramidal cell density in each hippocampal subregion, including CA1\u20104, prosubiculum (ProS), and subiculum was assessed in 166 cases encompassing various neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Alzheimer's disease\u2010associated p\u2010tau predominated in ProS, A\u03b2 in the CA1, and Lewy body\u2013related \u03b1\u2010synuclein in the CA2. The area density of protein deposits increased with the pathological stage until a peak, then decreased in cases with high pathology stages along with pyramidal cell density. Comorbid protein pathology influenced protein deposition patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This comprehensive evaluation reveals characteristic neurodegenerative disease\u2013related protein accumulation patterns in hippocampal subregions modified by co\u2010pathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Alzheimer's disease\u2013related phosphorylated tau predominates in the prosubiculum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid beta predominates in the CA1 and Lewy body\u2013related \u03b1\u2010synuclein in the CA2.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The area density of protein deposition increases with the disease stage up to a peak.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In the high pathology stage, protein deposition and pyramidal cell density decreases.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Comorbid protein pathology affects the pattern of protein accumulation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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