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We quantified regional perfusion from arterial spin labeling\u2010MRI (magnetic resonance imaging) and amyloid deposition from florbetapir\u2010positron emission tomography (PET) in a region comprising the posterior cingulate and precuneus (PCC+PCu), and additionally quantified perfusion in other regions important for cognitive decline (medial temporal lobe, inferior parietal lobe, and orbitofrontal cortex).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Participants with CIND displayed lower perfusion in the PCC+PCu relative to participants who were CN, but there was no statistically significant difference between the groups in amyloid burden in this region. In addition, participants with CIND exhibited lower inferior parietal and higher orbitofrontal perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Cerebral perfusion is related to cognitive status in the oldest\u2010old independent of amyloidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cerebral perfusion and amyloid positron emission tomography (PET) were measured in older adults: 90 years of age and older.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perfusion but not amyloid differed between cognitively impaired and normal groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Frontal and parietal regions linked to cognitive decline had altered perfusion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perfusion is related to cognitive status in the oldest\u2010old independent of amyloid.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.14357","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:35:55Z","timestamp":1731483355000},"page":"9068-9075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral perfusion and amyloidosis in the oldest\u2010old"],"prefix":"10.1002","volume":"20","author":[{"given":"Shubir","family":"Dutt","sequence":"first","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences University of California  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis C.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ahmad","family":"Sajjadi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana E.","family":"Greenia","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Kawas","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"},{"name":"Department of Neurobiology and Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Corrada","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California  Irvine California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-0658","authenticated-orcid":false,"given":"Daniel A.","family":"Nation","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology University of Southern California  Los Angeles California USA"},{"name":"Department of Physiology and Neuroscience, Zilkha 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