{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:18:36Z","timestamp":1790083116618,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007505","name":"Kirsten og Freddy Johansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG\u201023\u20101038904 QC"],"award-info":[{"award-number":["SG\u201023\u20101038904 QC"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016341","name":"Korea University Guro Hospital","doi-asserted-by":"publisher","award":["No.O2400251"],"award-info":[{"award-number":["No.O2400251"]}],"id":[{"id":"10.13039\/100016341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024\u2010ER1003\u201000"],"award-info":[{"award-number":["2024\u2010ER1003\u201000"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["No.RS\u20102021\u2010II212068"],"award-info":[{"award-number":["No.RS\u20102021\u2010II212068"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["Artificial Intelligence Innovation Hub"],"award-info":[{"award-number":["Artificial Intelligence Innovation Hub"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A5A2027340"],"award-info":[{"award-number":["NRF\u20102019R1A5A2027340"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2017\u201000915"],"award-info":[{"award-number":["#2017\u201000915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2022\u201000732"],"award-info":[{"award-number":["#2022\u201000732"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (A\u03b2)\u2010independent or A\u03b2\u2010dependent effects and improve the predictive performance of these biomarkers for A\u03b2 positivity on positron emission tomography (PET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 2935 participants underwent blood sampling for measurements of plasma A\u03b242\/40 ratio, phosphorylated tau 217 (p\u2010tau217; ALZpath), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels using\u00a0single\u2010molecule array and A\u03b2 PET. Laboratory findings were collected using a routine blood test battery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A\u03b2\u2010independent factors included hemoglobin and estimated glomerular filtration rate (eGFR) for p\u2010tau217 and hemoglobin, eGFR, and triiodothyronine (T\n                      <jats:sub>3<\/jats:sub>\n                      ) for GFAP and NfL. A\u03b2\u2010dependent factors included apolipoprotein E genotypes, body mass index status for A\u03b242\/40, p\u2010tau217, GFAP, and NfL. However, these factors exhibited negligible or modest effects on A\u03b2 positivity on PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings highlight the importance of accurately interpreting plasma biomarkers for predicting A\u03b2 uptake in real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We investigated factor\u2013Alzheimer's disease plasma biomarker associations in a large Korean cohort.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Hemoglobin and estimated glomerular filtration rate affect the biomarkers independently of brain amyloid beta (A\u03b2).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Apolipoprotein E genotypes and body mass index status affect the biomarkers dependent on brain A\u03b2.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Addition of A\u03b2\u2010independent factors shows negligible effect in predicting A\u03b2 positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Adjusting for A\u03b2\u2010dependent factors shows a\u00a0modest effect in predicting A\u03b2 positivity.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14368","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:38:52Z","timestamp":1731483532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Plasma Alzheimer's disease biomarker variability: Amyloid\u2010independent and amyloid\u2010dependent factors"],"prefix":"10.1002","volume":"21","author":[{"given":"Eun Hye","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"},{"name":"Department of Neurology Korea University Guro Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"},{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  G\u00f6teborg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong P.R. 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