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Lewy body dementias differed from AD by reduced levels of the autophagy protein p62 (\n                      <jats:italic>SQSTM1<\/jats:italic>\n                      ), whereas DLB was distinguished from both AD and PDD by altered TRIM33 and cysteine\/glutamate transporter (SLC7A11) across brain regions. An increase in mitochondrial and synaptic proteins was related to better cognition whereas enrichment in the\u00a0extracellular matrix, complement system, and autophagy proteins was associated with greater cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our study offers valuable insights into the network\u2010based biomarker characterization of molecular signatures of AD, DLB, and PDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Reduced levels of the autophagy protein p62 (\n                            <jats:italic>SQSTM1<\/jats:italic>\n                            ) differentiated Lewy body dementias from Alzheimer's disease (AD) across multiple brain regions.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Dementia with Lewy bodies (DLB) was distinguished from both AD and Parkinson's disease dementia (PDD) by altered TRIM33 and cysteine\/glutamate transporter (SLC7A11) levels across brain regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Key mitochondrial oxidative phosphorylation proteins (e.g., COX7A2, TOMM40L, NDUFV1), and synaptic proteins (e.g., GABRB3, GABRB2, GLUA3, GLUA4, SNAP47, dynamin1) were more abundant in preserved cognitive states.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Extracellular matrix proteins and members of the complement system (decorin, biglycan, C4A, C4B) showed a\u00a0strong positive correlation with cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14375","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:46:18Z","timestamp":1734932778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Anna","family":"Canal\u2010Garcia","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui M.","family":"Branca","sequence":"additional","affiliation":[{"name":"Department of 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