{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:00:16Z","timestamp":1791914416680,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171198 62303295"],"award-info":[{"award-number":["82171198 62303295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202140042"],"award-info":[{"award-number":["202140042"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>It remains unclear whether the local amyloid\u2010beta (A\u03b2) burden in key regions within the default mode network (DMN) affects network and cognitive functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F\u2010florbetapir positron emission tomography resting\u2010state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) A\u03b2 burden, DMN function, and cognitive function were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In individuals with high PRC A\u03b2 burden, there is a bidirectional relationship between DMN local function or functional connectivity and PRC A\u03b2 deposition across various cognitive states, which is also linked to cognitive function. Even below the\u00a0PRC A\u03b2 threshold, DMN function remains related to PRC A\u03b2 deposition and cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The findings reveal the critical role of PRC A\u03b2 deposition in disrupting neural networks associated with cognitive decline and the necessity of early detection and monitoring of PRC A\u03b2 deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Precuneus (PRC) A\u03b2 burden impacts DMN function in different cognitive stages.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>High PRC A\u03b2 burden is linked to early neural compensation and subsequent dysfunction.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Low PRC A\u03b2 burden correlates with neural changes before significant A\u03b2 accumulation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Changes in DMN function and connectivity provide insights into AD progression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Early detection of regional A\u03b2 burden can help monitor the risk of cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14380","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T05:53:27Z","timestamp":1731995607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association of precuneus A\u03b2 burden with default mode network function"],"prefix":"10.1002","volume":"21","author":[{"given":"Liang","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Gerontology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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