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Literature on late\u2010life brain health is limited, and findings on late\u2010life cognition are mixed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Pooling data from Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) and Study of Healthy Aging in African Americans (STAR) cohorts, we assessed the impact of childhood adversity (factor score from seven self\u2010reported items) on (a) executive function and verbal memory decline using linear mixed effects models (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02447), (b) structural magnetic resonance imaging (MRI) using linear regression (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0618), and (c) amyloid positron emission tomography (PET) using generalized linear models (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0331), all adjusting for early\u2010life demographic and socioeconomic confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Childhood adversity was not associated with cognition except for a slightly faster decline in verbal memory (\u00a0=\u00a0\u22120.013 SD\/year, 95% confidence interval [\u22120.025, \u22120.001]). Among neuroimaging outcomes, childhood adversity was associated with only larger temporal lobe volumes (\u00a0=\u00a00.092 SD [0.012, 0.173]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>More research evaluating sources of resilience, heterogeneity, and bias is needed to explain inconsistent findings across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We developed measurement models to capture childhood adversity in a diverse cohort.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Childhood adversity was associated with a slightly faster verbal memory decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We examined childhood adversity's effect on structural MRI and amyloid PET measures.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher childhood adversity was associated with larger temporal lobe volumes.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14388","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T06:36:13Z","timestamp":1733466973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Childhood adversity and late\u2010life cognitive and brain health in a diverse cohort"],"prefix":"10.1002","volume":"21","author":[{"given":"Eleanor","family":"Hayes\u2010Larson","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of California Los Angeles Fielding School of Public Health  Los Angeles California USA"},{"name":"Leonard Davis School of Gerontology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie M.","family":"Gradwohl","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of California Los Angeles Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of California Los Angeles Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay C.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gilsanz","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Pleasanton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Whitmer","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Pleasanton California USA"},{"name":"Department of Public Health Sciences University of California, Davis School of Medicine  Davis California USA"},{"name":"Department of Neurology University of California Davis School of Medicine  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Maria","family":"Glymour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karestan C.","family":"Koenen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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