{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:02:19Z","timestamp":1787868139555,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010771","name":"Loo och Hans Ostermans Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2023\u201001699"],"award-info":[{"award-number":["2023\u201001699"]}],"id":[{"id":"10.13039\/100010771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceutica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case\u2013control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>From the Swedish national registers, we included 88,065 incident dementia cases aged \u2265\u00a070 at diagnosis between 2011 and 2016 and 880,650 age\u2010 and sex\u2010matched controls. Cardiovascular drug use was ascertained from the Prescribed Drug Register.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Long\u2010term users (\u2265 5\u00a0years) of antihypertensives, diuretics, lipid\u2010lowering drugs (LLDs), and oral anticoagulants (OACs) had statistically significantly fewer dementia diagnoses (odds ratio [OR] 0.75\u20130.91) than non\u2010users. Antiplatelets use was associated with more dementia diagnoses (OR 1.13\u20131.25). Use of antihypertensives in combination with diuretics, LLDs, and OACs for \u2265\u00a05 years was associated with fewer dementia diagnoses (OR 0.66\u20130.84).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Preventing dementia via cardiovascular drug pathways may be possible. It is however important to consider the potential long\u2010term negative cognitive effect of antiplatelets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Use \u2265\u00a05 years of common cardiovascular drugs was associated with lower dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Common cardiovascular drug combination use was associated with lower dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Anti\u2010platelet use of any duration was associated with higher dementia risk.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14389","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T08:49:53Z","timestamp":1731919793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of common cardiovascular disease drugs and risk of dementia: A case\u2013control study in Swedish national register data"],"prefix":"10.1002","volume":"21","author":[{"given":"Mozhu","family":"Ding","sequence":"first","affiliation":[{"name":"Unit of Epidemiology, Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology, Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska 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