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   <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all\u2010cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow\u2010up in the community\u2010based Framingham Heart Study Offspring cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One thousand four hundred eighty\u2010seven participants (mean\u00a0\u00b1\u00a0standard deviation, age in years 69\u00a0\u00b1\u00a06) completed food frequency questionnaires (FFQs) and had incident all\u2010cause dementia and AD surveillance data available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Two hundred forty\u2010six participants developed all\u2010cause dementia (including AD,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0187) over a median follow\u2010up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all\u2010cause dementia and AD after adjustment for demographic, lifestyle, and clinical covariates (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.10\u20131.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; HR 1.20, 95% CI: 1.07\u20131.34d,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Higher DII scores were associated with a higher risk of incident all\u2010cause dementia and AD. Although these promising findings need to be replicated and further validated, our results suggest that diets that correlate with low DII scores may prevent late\u2010life dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Higher Dietary Inflammatory Index (DII) scores were associated with an increased incidence of all\u2010cause dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher DII scores were associated with an increased incidence of Alzheimer's disease dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Diets that correlate with low DII scores may prevent late\u2010life dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14390","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:00:54Z","timestamp":1733468454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between dietary inflammatory index score and incident dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-9289","authenticated-orcid":false,"given":"Debora Melo","family":"van Lent","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases UT Health San Antonio San Antonio Texas USA"},{"name":"Department of Neurology Boston University School of Medicine Boston Massachusetts USA"},{"name":"The Framingham Heart Study Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Gokingco","family":"Mesa","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases UT Health San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan I.","family":"Short","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases UT Health San Antonio San Antonio Texas USA"},{"name":"Tufts Clinical and Translational Science Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitzi M.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases UT Health San Antonio San Antonio Texas USA"},{"name":"Department of Neurology Cedars Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo J.","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Public Health Zhejiang University Medical School Hangzhou China"},{"name":"Department of Nutrition Harvard T.H. 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