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We also observed important\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54\u2013associated differences in cognitively unimpaired individuals who converted to mild cognitive impairment\/AD versus those who did not convert.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      This observed heterogeneity in neuroimaging biomarkers between\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers versus non\u2010carriers may have important implications regarding the prevention, diagnosis, and treatment of AD in different subpopulations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            An extensive study was performed on the apolipoprotein E (\n                            <jats:italic>APOE<\/jats:italic>\n                            ) \u03b54\u2013associated heterogeneity in neuroimaging biomarkers from the Alzheimer's Disease Neuroimaging Initiative.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Robust\n                            <jats:italic>APOE<\/jats:italic>\n                            \u03b54\u2013associated increases in amyloid beta (A\u03b2) deposition throughout the brain, in every diagnostic group, were observed.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>APOE<\/jats:italic>\n                            \u03b54\u2013associated increases in tau pathology, decreases in glucose uptake, and increases in brain atrophy, which expand in regional scope and magnitude with disease progression, were observed.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Significant sex\u2010 and age\u2010related differences in\n                            <jats:italic>APOE<\/jats:italic>\n                            \u03b54\u2013associated neuroimaging biomarker heterogeneity, with overall increases in pathological presentation in female\n                            <jats:italic>APOE<\/jats:italic>\n                            \u03b54 carriers, were observed.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Regional differences in A\u03b2 deposition, tau accumulation, glucose uptake, ventricle size, and white matter hyperintensities were observed in cognitively normal participants who converted to mild cognitive impairment\/Alzheimer's disease, which may hold potential predictive value.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14392","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T06:07:58Z","timestamp":1732255678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>APOE<\/i>\n                    \u03b54\u2013associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum"],"prefix":"10.1002","volume":"21","author":[{"given":"Jason","family":"Mares","sequence":"first","affiliation":[{"name":"Taub 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