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Mixed effects models assessed group differences in retrospective cognitive and plasma pTau217 trajectories.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n T+\n MTL&Neo<\/jats:sub>\n was the most common T+ group (\n n<\/jats:italic>\n \u00a0=\u00a097; 93% A+) and exhibited the sharpest worsening in cognitive and pTau217 trajectories before tau PET.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n The T+\n MTL&Neo<\/jats:sub>\n category represents an intermediate to advanced stage of AD preceded by rising ptau217 and progressive cognitive decline. The pTau217 finding suggests that A+, T+ in MTL or neocortex could represent early AD stages, with a higher likelihood of progressing to more advanced stages.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n \n Visual assessments of Tau\u2010PET FQT revealed four distinct uptake groups: tau\u2010negative (T\u2212), MTL\u2010only (T+\n MTL<\/jats:sub>\n ), neocortex\u2010only (T+\n Neo<\/jats:sub>\n ), or both (T+\n MTL&Neo<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:list-item>\n \n \n Amyloid positive participants in the T+\n MTL<\/jats:sub>\n and T+\n MTL&Neo<\/jats:sub>\n categories showed a retrospectively faster decline in their cognitive trajectories, and a sharper increase in pTau217 levels in plasma, compared to T\u2212.\n <\/jats:p>\n <\/jats:list-item>\n \n \n The T+\n MTL&Neo<\/jats:sub>\n group displayed sharper trajectories compared with the other Tau positive groups in both their cognitive scores and pTau217 plasma levels.\n <\/jats:p>\n <\/jats:list-item>\n \n Our results suggest that participants with Tau present in both MTL and neocortex represent an intermediate to advanced stage of AD, whereas participants with signals confined to either MTL or neocortex could represent earlier AD stages.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14406","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:06:40Z","timestamp":1731996400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Visual read of [F\u201018]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-282X","authenticated-orcid":false,"given":"Ramiro 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