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The NUcleic acid Linked Immuno\u2010Sandwich Assay (NULISA) is a technology that requires 15\u00a0\u00b5L of sample to measure more than 100 analytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We compared AD\u2010relevant biomarkers included in the NULISA against validated assays in cerebrospinal fluid (CSF) and plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CSF measures of amyloid beta 42\/40, and phosphorylated tau (p\u2010tau)217 are highly correlated when measured by immunoassay, mass spectrometry, or NULISA. In plasma, p\u2010tau217 performance is similar to that reported with other technologies when predicting amyloidosis. Other biomarkers show a wide range of correlation values depending on the fluid and the platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The NULISA multiplexed platform produces reliable results for established biomarkers in CSF that are useful in research settings, with the advantage of measuring additional biomarkers using minimal sample volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We tested the novel technology NUcleic acid Linked Immuno\u2010Sandwich Assay (NULISA) in the dementia research setting.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NULISA multiplexed platform produces reliable results for established and emerging biomarkers using minimal sample volume.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cerebrospinal fluid measures of amyloid beta 42\/40, and phosphorylated tau (p\u2010tau)217 are highly correlated when measured by immunoassay, mass spectrometry, or NULISA.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In plasma, p\u2010tau217 performance is similar to that reported with other technologies when predicting amyloidosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NULISA measures are useful in research settings, with the advantage of measuring additional biomarkers using minimal sample volume.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14413","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T07:13:36Z","timestamp":1732259616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Benchmarking of a multi\u2010biomarker low\u2010volume panel for Alzheimer's disease and related dementia research"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-7059","authenticated-orcid":false,"given":"Laura","family":"Ibanez","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"NeuroGenomics and Informatics Center Washington University School of Medicine  St. 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