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VEGF\u2010associated intercellular communication was also profiled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher microglia\n                      <jats:italic>FLT1<\/jats:italic>\n                      , endothelial\n                      <jats:italic>FLT4<\/jats:italic>\n                      , and oligodendrocyte\n                      <jats:italic>VEGFB<\/jats:italic>\n                      are associated with greater amyloid beta (A\u03b2) load, whereas higher\n                      <jats:italic>VEGFB<\/jats:italic>\n                      expression in inhibitory neurons is associated with lower A\u03b2 load. Higher astrocyte\n                      <jats:italic>NRP1<\/jats:italic>\n                      is associated with lower tau density. Higher microglia and endothelial\n                      <jats:italic>FLT1<\/jats:italic>\n                      are associated with worse cognition performance. Endothelial and microglial\n                      <jats:italic>FLT1<\/jats:italic>\n                      expression was upregulated in clinical AD patients compared to cognitively normal controls. Finally, AD cells showed a significant reduction in VEGF signaling compared to controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our results highlight key changes in VEGF receptor expression in endothelial and microglial cells during AD, and the potential protective role of VEGFB in neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            The prefrontal cortical expression of\n                            <jats:italic>FLT1<\/jats:italic>\n                            and\n                            <jats:italic>FLT4<\/jats:italic>\n                            was associated with worse cross\u2010sectional global cognitive function, longitudinal cognitive trajectories, and more Alzheimer's disease (AD) neuropathology.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            The associations between\n                            <jats:italic>FLT1<\/jats:italic>\n                            or\n                            <jats:italic>FLT4<\/jats:italic>\n                            and AD endophenotypes appear to be driven by endothelial and microglial cells.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            <jats:italic>VEGFB<\/jats:italic>\n                            expression seems to have opposing effects on the A\u03b2 burden in AD depending on cell types, highlighting its potential protective role in neurons.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14419","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T06:53:45Z","timestamp":1733468025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution"],"prefix":"10.1002","volume":"21","author":[{"given":"Yiyang","family":"Wu","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B.","family":"Libby","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center 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