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Plasma BD\u2010tau diagnostic accuracy increased when ratioed to plasma p\u2010tau217, matching CSF 14\u20103\u20103. Plasma BD\u2010tau levels were associated with survival (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001), outperforming t\u2010tau and NfL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma BD\u2010tau is a valuable marker for CJD prognostication. In the clinical setting, the plasma BD\u2010tau\/p\u2010tau217 ratio provides an accurate, fast marker supporting the clinical diagnosis of CJD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The increase of plasma BD\u2010tau levels parallels that of CSF t\u2010tau in CJD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF p\u2010tau217 levels are significantly increased in CJD, reflecting a prion\u2010specific secondary tauopathy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 shows a distinct profile than CSF p\u2010tau217 in CJD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma BD\u2010tau\/p\u2010tau217 ratio is as accurate as CSF 14\u20103\u20103 in distinguishing CJD from np\u2010RPDs, including AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>BD\u2010tau represents a valuable blood\u2010based biomarker for CJD prognostication.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14422","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:04:01Z","timestamp":1733468641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical value of novel blood\u2010based tau biomarkers in Creutzfeldt\u2013Jakob disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Giuseppe Mario","family":"Bentivenga","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gonzalez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Lab Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Baiardi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM) University of Bologna  Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn\u2010Eivind","family":"Kirsebom","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of North Norway  Troms\u00f8 Norway"},{"name":"Department of Psychology Faculty of Health Sciences The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Neurology Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mastrangelo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mammana","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna 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UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Lab Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Paris Brain Institute ICM Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University  Paris France"},{"name":"Neurodegenerative Disorder Research Center Division of Life Sciences and Medicine and Department of Neurology Institute on Aging and Brain Disorders University of Science and Technology of China and First Affiliated Hospital of USTC  Hefei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Parchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DiBiNeM) University of Bologna  Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010012\u20101002\u20108"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002350\u2010y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30477\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101683\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4614"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002661\u20102"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001220"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6455"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51873"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38737"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00824"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7131.577"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102020\u2010323826"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000815\u20106"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001045\u2010w"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1071"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13516"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13907"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010009\u20100585\u20101"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170231"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001093\u20106"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047286\u20105"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13525"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010023\u201002663\u20100"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001300\u2010y"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30071\u20105"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac407"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.21554"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12411"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000380\u20107"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.13855"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105106"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.10.009"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12214"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010006\u20100472\u20109"}],"container-title":["Alzheimer's &amp; 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