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Spindles and SOs mediated the effect of phosphorylated tau 181 (pTau181)\/A\u03b242 on cognition, while pTau181\/a\u03b242 moderated the effect of spindles and SOs on cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non\u2010invasive biomarkers of neurodegeneration and cognition in AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Sleep spindles predict long\u2010term cognitive performance in AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep spindle and SOs can be predictive, non\u2010invasive biomarkers for AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep may be one of the most important modifiable risk factors for AD progression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep microarchitecture is a novel therapeutic target for preserving brain heath.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep physiology can provide novel therapeutic targets to slow AD progression.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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