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However, the extent to which common medical conditions affect biomarker performance remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0348) included individuals without cognitive impairment. We studied how brain A\u03b2 associated with BBMs (A\u03b242\/40, phosphorylated tau [p\u2010tau] 181 and 217, p\u2010tau217\/A\u03b242, glial fibrillary acidic protein [GFAP], and neurofilament light [NfL]) and optimal BBM thresholds for predicting brain A\u03b2 positivity and whether they are obscured by the presence of common medical conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Plasma A\u03b242\/40, p\u2010tau181, p\u2010tau217, and GFAP, but not NfL, were significantly associated with brain A\u03b2. P\u2010tau217\/A\u03b242 showed the best discriminative performance (area under the curve: 0.91). The strength of p\u2010tau217\u2013brain A\u03b2 associations were obscured by diabetes and cardiovascular conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These results suggest BBMs may help detect early A\u03b2 pathology but suggest caution in their use due to common medical conditions that could affect accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma A\u03b242\/40, p\u2010tau181, p\u2010tau217, and GFAP but not NfL showed significant associations with brain A\u03b2.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>BBMs were more strongly associated with the level of brain A\u03b2 in those without diabetes and cardiovascular conditions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>P\u2010tau217\/A\u03b242 showed the best performance (AUC\u00a0=\u00a00.91) in discriminating A\u03b2 presence with an optimal cut\u2010off of\u00a0&gt;1.2, followed by p\u2010tau217 at\u00a0&gt;0.46 pg\/mL, with performance slightly improving when excluding participants with cardiovascular conditions.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14430","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:24:40Z","timestamp":1733469880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Influence of medical conditions on the diagnostic accuracy of plasma p\u2010tau217 and p\u2010tau217\/A\u03b242"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-1647","authenticated-orcid":false,"given":"Marcos","family":"Olvera\u2010Rojas","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey R.","family":"Sewell","sequence":"additional","affiliation":[{"name":"AdventHealth Research Institute  Orlando Florida USA"},{"name":"Centre for Healthy Ageing, Health Futures Institute Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh 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