{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:09:18Z","timestamp":1789560558190,"version":"build-2803163510"},"reference-count":92,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms (NPSs) are common in dementia with Lewy bodies (DLB) but their neurobiological mechanisms are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      NPSs and cognition were assessed annually in participants (DLB\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0222; Alzheimer's disease [AD]\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0125) from the European DLB (E\u2010DLB) Consortium, and plasma phosphorylated tau\u2010181 (p\u2010tau181) and p\u2010tau231 concentrations were measured at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Hallucinations, delusions, and depression were more common in DLB than in AD and, in a subgroup with longitudinal follow\u2010up, persistent hallucinations and NPSs were associated with lower p\u2010tau181 and p\u2010tau231 in DLB. In adjusted linear mixed\u2010effects models, hallucinations at baseline were associated with greater longitudinal cognitive impairment in DLB, with a significant interaction with p\u2010tau231.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Higher p\u2010tau181 and p\u2010tau231 levels were associated with a lower longitudinal risk of NPSs and hallucinations in early\u2010stage DLB. However, the interaction between hallucinations and p\u2010tau231 suggests that when AD co\u2010pathology and hallucinations do co\u2010exist in DLB that they may synergistically exacerbate cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Neuropsychiatric symptoms (NPSs) were more common in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower plasma phosphorylated tau\u2010231 (p\u2010tau231) and p\u2010tau181 levels were associated with persistent hallucinations in DLB.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower plasma p\u2010tau231 and p\u2010tau181 levels were associated with an increased risk of persistent NPSs in early DLB.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Hallucinations at baseline were associated with greater cognitive dysfunction in DLB, and there was an interaction with p\u2010tau231.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14434","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T21:18:23Z","timestamp":1735420703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies"],"prefix":"10.1002","volume":"21","author":[{"given":"Lucy L.","family":"Gibson","sequence":"first","affiliation":[{"name":"Centre for Healthy Brain Ageing Department of Psychological Medicine Institute of Psychiatry Psychology, and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Quality and Health Technology Faculty of Health Sciences University of Stavanger Stavanger Norway"},{"name":"The Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway"},{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing Department of Psychological Medicine Institute of Psychiatry Psychology, and Neuroscience King's College London London UK"},{"name":"Centre for 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