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Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Greater BAG (older\u2010looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger\u2010looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white\u2010matter alterations, inflammation, high glucose, poorer vascular\u2010related cognitive domains. Sex\u2010specific associations were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Vascular\u2010related lifestyles and health shape brain appearance. Inflammation and insulin\u2010related processes may be keys to understanding vascular cognitive disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>BAG, reflecting deviations from CA, can indicate resilience.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Diabetes, stroke, and low physical activity link to \u201colder\u201d brains (greater BAG).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Physical activity yielded to \u201cyounger\u201d brains in septuagenarians with obesity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>High cerebrovascular burden, inflammation, and glucose associate with \u201colder\u201d brains.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sex differences were detected in all BAG\u2010associated factors.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14435","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:00:47Z","timestamp":1734678047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biological brain age and resilience in cognitively unimpaired 70\u2010year\u2010old 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