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Longitudinal change in ADRC plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n and cognition and cross\u2010sectional associations with SAMS memory and tau positron emission tomography (PET) were examined.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n exhibited high performance in detecting amyloid positivity defined by PET (area under the curve [AUC]: 0.885, 95% confidence interval [CI]: 0.816\u20130.955). Once abnomal, plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n remained low and predicted cognitive decline in both CU and CI individuals. Among SAMS CU, plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n was associated with poorer hippocampal\u2010dependent memory and elevated tau accumulation.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n Lumipulse plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n is a scalable assay for detection of cerebral A\u03b2 and prediction of risk for cognitive decline across the AD continuum.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n \n Lumipulse plasma amyloid beta (A\u03b2)\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n exhibited\u00a0high accuracy in detecting amyloid positivity.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Plasma amyloid\u2010positive (A\u03b2+) individuals exhibited stability of A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n over time.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n predicted future cognitive decline across the Alzheimer's disease (AD) spectrum.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Plasma A\u03b2\n 42<\/jats:sub>\n \/A\u03b2\n 40<\/jats:sub>\n was sensitive to memory and tau burden in clinically unimpaired older adults.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14442","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:25:17Z","timestamp":1734935117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Plasma A\u03b2\n 42<\/sub>\n \/A\u03b2\n 40<\/sub>\n is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum"],"prefix":"10.1002","volume":"21","author":[{"given":"Alexandra N.","family":"Trelle","sequence":"first","affiliation":[{"name":"Neurology & Neurological Sciences Stanford University School of Medicine Stanford California 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