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We systematically reviewed studies that reported the diagnostic accuracy of plasma and CSF p\u2010tau217, searching MEDLINE\/PubMed, Scopus, and Web of Science through August 2024. The accuracy of p\u2010tau217 in predicting amyloid and tau pathology on PET was evaluated in 30 studies. Both plasma and CSF p\u2010tau217 effectively detect amyloid and tau PET deposition. Plasma p\u2010tau217 showed 82% sensitivity for detecting amyloid and 83% for tau, with 86% and 83% specificity, respectively. CSF p\u2010tau217 had 79% sensitivity for amyloid and 91% for tau, with 91% and 84% specificity. p\u2010tau217 effectively identifies Alzheimer's disease (AD) pathology. Plasma p\u2010tau217 was comparable to CSF p\u2010tau217 in detecting amyloid deposition on PET. Despite being less sensitive for detecting tau deposition on PET, plasma p\u2010tau217 can be an efficient screening tool for underlying AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma phosphorylated tau 217 (p\u2010tau217) serves as a viable biomarker alternative to cerebrospinal fluid p\u2010tau217 due to the strong concordance between their results.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 accurately identifies amyloid and tau positron emission tomography (PET) positivity, exhibiting a low rate of false negatives and positives, thereby establishing it as a reliable diagnostic tool for Alzheimer's disease (AD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 demonstrates slightly higher accuracy in predicting amyloid PET positivity compared to tau PET positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 demonstrates higher predictive accuracy in detecting AD pathology among cognitively impaired individuals, compared to cognitively unimpaired individuals, suggesting its enhanced utility as a diagnostic biomarker in clinical settings.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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