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The primary outcome was incident all\u2010cause dementia. Pre\u2010specified subgroups were defined by dementia risk factors (age, sex, education, apolipoprotein E [\n                      <jats:italic>APOE<\/jats:italic>\n                      ] genotype, cognitive status, and cardiovascular risk factors).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Four hundred eighty\u2010six participants developed dementia during 37,782 person\u2010years of follow\u2010up. Higher incidence was associated with baseline age,\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 genotype, physical inactivity, Mini\u2010Mental State Examination, and blood pressure. Multidomain intervention had no effect on incident dementia overall (hazard ratio =\u00a00.98, 95% confidence interval 0.80\u20131.21), or in any pre\u2010specified subgroup. A recursive partitioning algorithm also did not detect any subgroups, defined by single or multiple risk factors, showing a differential intervention effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We did not identify any subgroups of older adults in whom multidomain interventions significantly reduced incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>MAPT: NCT00672685 (clinicaltrials.gov); PreDIVA: ISRCTN29711771 (ISRCTN registry)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We pooled up to 12 years of follow\u2010up data from two multidomain prevention trials.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Five thousand two hundred five participants aged \u2265 70 were included.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Subgroups were pre\u2010defined by modifiable and non\u2010modifiable dementia risk factors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A data\u2010driven recursive partitioning algorithm was also used.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multidomain intervention did not lower incident dementia overall or in any subgroup.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14472","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T08:16:06Z","timestamp":1737101766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-824X","authenticated-orcid":false,"given":"Nicola","family":"Coley","sequence":"first","affiliation":[{"name":"Aging Research Team Centre for Epidemiology and Research in Population health (CERPOP) INSERM\u2010University of Toulouse UPS  Toulouse France"},{"name":"Department of Epidemiology and Public Health Toulouse University Hospital  Toulouse France"},{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke P.","family":"Hoevenaar\u2010Blom","sequence":"additional","affiliation":[{"name":"Department of General Practice Amsterdam UMC, Location AMC  Amsterdam the Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC, Location VUMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Shourick","sequence":"additional","affiliation":[{"name":"Aging Research Team Centre for Epidemiology and Research in Population health (CERPOP) INSERM\u2010University of Toulouse UPS  Toulouse France"},{"name":"Department of Epidemiology and Public Health Toulouse University Hospital  Toulouse France"},{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P. Moll","family":"van Charante","sequence":"additional","affiliation":[{"name":"Department of General Practice Amsterdam UMC, Location AMC  Amsterdam the Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC, Location VUMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Willem","family":"van Dalen","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Centre for Brain Behaviour and Cognition Radboud University Medical Centre  Nijmegen the Netherlands"},{"name":"Department of Neurology Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"van Gool","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health Amsterdam UMC, Location VUMC  Amsterdam the 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