{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:08:56Z","timestamp":1789560536200,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C0530"],"award-info":[{"award-number":["HI18C0530"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Alzheimer's disease (AD) is now diagnosed biologically. Since subjective cognitive decline (SCD) may indicate preclinical AD, assessing AD\u2010biomarkers is crucial. We investigated cognitive and neurodegenerative trajectories in SCD over 24 months based on biomarker positivity, and evaluated the predictive value of plasma biomarkers.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The CoSCo prospective cohort included older adults with SCD. Participants were categorized into high\u2010 and low\u2010risk groups based on plasma biomarkers (amyloid beta [A\u03b2] 42\/40, phosphorylated tau 181 [p\u2010tau181], and glial fibrillary acidic protein [GFAP]), and magnetic resonance imaging (MRI) findings to compare outcomes.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n High\u2010risk SCDs (\n n<\/jats:italic>\n \u00a0=\u00a023, 23%) revealed greater decline in general cognition, memory recall, frontal function, and hippocampal volumes compared to low\u2010risk SCDs. Combined scores of plasma and MRIs yielded the best predictions compared with other biomarker categories.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n SCD participants with high\u2010risk experience faster cognitive and neurodegenerative declines. A combination of plasma biomarkers and MRIs could be used for screening and prognosis.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n This is part of a multicenter prospective cohort study in Korea.<\/jats:p>\n <\/jats:list-item>\n \n We investigated cognitive and atrophic trajectories in SCD over 24 months.<\/jats:p>\n <\/jats:list-item>\n \n High risk SCDs revealed greater cognitive decline and hippocampal atrophy.<\/jats:p>\n <\/jats:list-item>\n \n Integration of plasma and MRIs yielded better predictions than other categories.<\/jats:p>\n <\/jats:list-item>\n \n Risk stratification using plasma and MRIs can be used for screening and prognosis.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14473","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T21:38:38Z","timestamp":1735421918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive and neurodegenerative trajectories of subjective cognitive decline according to baseline biomarkers: Results of the CoSCo study"],"prefix":"10.1002","volume":"21","author":[{"given":"Yun Jeong","family":"Hong","sequence":"first","affiliation":[{"name":"Neurology Uijeongbu St. Mary's Hospital The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Neurology Inha University College of Medicine Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Neurology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Neurology, Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Neurology College of Medicine, Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jeong","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology, ROA clinic Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungmin","family":"Kang","sequence":"additional","affiliation":[{"name":"Research and Development, PeopleBio Inc. Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul St. Mary's Hospital The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CoSCo study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2017.16.2.40"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519766"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.12.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13651"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01273-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2022.21.4.147"},{"key":"e_1_2_9_11_1","volume-title":"Seoul Neuropsychological Screening Battery II","author":"Kang Y","year":"2012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0755-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-019-00164-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.06.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10120974"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.107185"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.08.012"},{"key":"e_1_2_9_23_1","first-page":"8","article-title":"The reliability and validity of the Korean Instrumental Activities of Daily Living (K\u2010IADL)","volume":"20","author":"Kang SJ","year":"2002","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00989-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.002"}],"updated-by":[{"DOI":"10.1002\/alz.70210","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000}}],"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.14473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:42:57Z","timestamp":1789558977000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/alz.14473"],"URL":"https:\/\/doi.org\/10.1002\/alz.14473","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14473"}}