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This study assessed the potential of plasma biomarkers for differential diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This cohort study included 374 participants (96 AD, 278 FTLD). Plasma phosphorylated tau (p\u2010tau)\n                      <jats:sub>217<\/jats:sub>\n                      , neurofilament light chain (NfL), brain\u2010derived tau, glial fibrillary acidic protein, and the amyloid beta\n                      <jats:sub>1\u201042<\/jats:sub>\n                      \/\n                      <jats:sub>1\u201040<\/jats:sub>\n                      ratio were measured. Receiver operating characteristic curve analyses assessed diagnostic accuracy, and a three\u2010range threshold approach was used to stratify patients based on the most accurate biomarker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau\n                      <jats:sub>217<\/jats:sub>\n                      effectively distinguished AD from FTLD, with the NfL\/p\u2010tau\n                      <jats:sub>217<\/jats:sub>\n                      ratio showing superior accuracy. The three\u2010range approach identified thresholds with 95% and 97.5% sensitivity and specificity, reducing the need for cerebrospinal fluid testing by 75% and 54%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau\n                      <jats:sub>217<\/jats:sub>\n                      and the NfL\/p\u2010tau\n                      <jats:sub>217<\/jats:sub>\n                      ratio are promising non\u2010invasive biomarkers for differentiating AD from FTLD, suggesting their use as a potential alternative to traditional diagnostic methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Plasma phosphorylated tau (p\u2010tau)\n                            <jats:sub>217<\/jats:sub>\n                            distinguishes Alzheimer's disease (AD) from frontotemporal lobar degeneration (FTLD) with high accuracy.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            The neurofilament light chain\/p\u2010tau\n                            <jats:sub>217<\/jats:sub>\n                            ratio showed the highest accuracy for differentiating AD from FTLD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A three\u2010range threshold reduces the need for invasive cerebrospinal fluid testing or amyloid positron emission tomography imaging.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14482","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:28:21Z","timestamp":1736328501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Plasma p\u2010tau\n                    <sub>217<\/sub>\n                    and neurofilament\/p\u2010tau\n                    <sub>217<\/sub>\n                    ratio in differentiating Alzheimer's disease from syndromes associated with frontotemporal lobar degeneration"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6940","authenticated-orcid":false,"given":"Alberto","family":"Benussi","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences University of Trieste  Trieste 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