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Participants underwent overnight polysomnography (PSG), amyloid \u03b2 (A\u03b2) positron emission tomography (PET), and plasma biomarker analysis: phosphorylated tau at threonine 181 (p\u2010tau181), neurofilament light (NfL), and brain\u2010derived neurotrophic factor (BDNF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After adjusting for demographics, apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 status, cognition, and comorbidities, the highest tertile of REM latency was associated with higher A\u03b2 burden (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.08, 95% confidence interval [CI]: 0.03 to 0.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), elevated p\u2010tau181 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.19, 95% CI: 0.02 to 0.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), and reduced BDNF levels (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u20100.47, 95% CI: \u20130.68 to \u20130.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013), compared to the lowest tertile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Prolonged REM latency may serve as a novel marker or risk factor for AD\/ADRD pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Rapid eye movement latency (REML) may be a potential marker for Alzheimer's disease and Alzheimer's disease and related dementias (AD\/ADRD) pathogenesis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Prolonged REML was associated with higher amyloid beta (A\u03b2) burden, phosphorylated tau\u2010181 (p\u2010tau181), and lower brain\u2010derived neurotrophic factor (BDNF) levels.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Intervention trial is needed to determine if targeting REML can modify AD\/ADRD risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Slow\u2010wave sleep was not associated with AD\/ADRD biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14495","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:01:57Z","timestamp":1737961317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-7732","authenticated-orcid":false,"given":"Jiangli","family":"Jin","sequence":"first","affiliation":[{"name":"Clinical Trial Research Center China\u2010Japan Friendship Hospital Beijing China"},{"name":"Peking University China\u2010Japan Friendship School of Clinical Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Cavaill\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California San Francisco California USA"},{"name":"Department of Neurology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Winer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University School of Medicine Palo Alto California 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