{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:49:12Z","timestamp":1793566152935,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Using an Asian cohort with high prevalence of concomitant cerebrovascular disease (CeVD), we evaluated the performance of a plasma immunoassay for tau phosphorylated at threonine 217 (p\u2010tau217) in detecting amyloid beta positivity (A\u03b2+) on positron emission tomography and cognitive decline, based on a three\u2010range reference, which stratified patients into low\u2010, intermediate\u2010, and high\u2010risk groups for A\u03b2+.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Brain amyloid status (A\u03b2\u2013 [\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0142] vs A\u03b2+ [\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a073]) on amyloid PET scans was assessed along with the plasma ALZpath p\u2010tau217 assay to derive three\u2010range reference points for PET A\u03b2+ based on 90% sensitivity (lower threshold) and 90% specificity (upper threshold).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Plasma p\u2010tau217 (area under the curve [AUC]\u00a0=\u00a00.923) outperformed routine clinical assessments (AUC\u00a0=\u00a00.760\u20130.819;\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.003) and other plasma biomarkers (AUC\u00a0=\u00a00.817\u20130.834;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The high\u2010risk group showed significantly higher rates of cognitive decline than the low\u2010risk group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Risk stratification for PET A\u03b2+ based on a plasma p\u2010tau217 assay demonstrated potential diagnostic and prognostic utility in an Asian cohort with concomitant CeVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The utility of plasma p\u2010tau217 to detect brain amyloid beta pathology (A\u03b2+) was studied in an Asian cohort with concomitant cerebrovascular disease<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma tau phosphorylated at threonine 217 (p\u2010tau217) showed superior utility in detecting A\u03b2+ compared to neuroimaging measures, clinical workup, or other blood biomarkers including p\u2010tau181, glial fibrillary protein (GFAP), and A\u03b2<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher plasma p\u2010tau217 correlated with faster cognitive decline<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 shows promise as an Alzheimer's disease (AD) diagnostic and prognostic biomarker in diverse populations<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14502","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:41:51Z","timestamp":1736836911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Clinical utility of plasma p\u2010tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Joyce R.","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Singapore Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore and National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Yeow","family":"Tan","sequence":"additional","affiliation":[{"name":"St Luke's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[{"name":"Raffles Neuroscience Centre Raffles Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00f6ll","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"Department of Neuropsychiatry Sahlgrenska University Hospital  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  G\u00f6teborg Sweden"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases  Hong Kong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  G\u00f6teborg Sweden"},{"name":"Paris Brain Institute ICM Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Sorbonne University  Paris France"},{"name":"Neurodegenerative Disorder Research Center Division of Life Sciences and Medicine and Department of Neurology Institute on Aging and Brain Disorders University of Science and Technology of China and First Affiliated Hospital of USTC  Hefei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, the Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-1424","authenticated-orcid":false,"given":"Mitchell K. 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