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Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n The Alzheimer's Association Global Biomarker Standardization Consortium conducted a blinded case\u2013control study to learn which phosphorylated tau (p\u2010tau) assays provide the largest fold\u2010changes in Alzheimer's disease (AD) versus non\u2010AD and show commutability in measuring patient samples and candidate certified reference materials (CRMs).<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Thirty\u2010three different p\u2010tau assays measured paired plasma and cerebrospinal fluid (CSF) from 40 participants (25 with \u201cAD pathology\u201d and 15 with \u201cnon\u2010AD pathology\u201d by CSF amyloid beta [A\u03b2]42\/A\u03b240 and p\u2010tau181 criteria). Four CRMs were assessed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Plasma p\u2010tau217 demonstrated higher fold\u2010changes between AD and non\u2010AD than other p\u2010tau epitopes. Fujirebio LUMIPULSE G, UGOT IPMS, and Lilly MSD p\u2010tau217 provided the highest fold\u2010changes. Plasma p\u2010tau217 showed the strongest correlations between plasma assays (rho\u00a0=\u00a00.81\u20130.97). The CRMs were not commutable across assays.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Plasma p\u2010tau217 showed larger fold\u2010changes and better accuracy for detecting AD pathology in symptomatic individuals, with greater cross\u2010platform agreement than other p\u2010tau variants. Further work is needed to develop suitable CRMs facilitating cross\u2010assay standardization.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Paired plasma and cerebrospinal fluid (CSF) samples from twenty\u2010five Alzheimer's disease (AD) and 15 non\u2010AD patients were measured blind.<\/jats:p>\n <\/jats:list-item>\n \n Thirty\u2010three plasma assays were compared, for phosphorylated tau\u2010181 (p\u2010tau181), 205, 212, 217 and 231.<\/jats:p>\n <\/jats:list-item>\n \n Plasma p\u2010tau217 consistently had the highest fold\u2010change and was best correlated between assays.<\/jats:p>\n <\/jats:list-item>\n \n Plasma\u2010CSF correlations were weak to moderate.<\/jats:p>\n <\/jats:list-item>\n \n There was lack of commutability for four candidate reference materials.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14508","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:12:02Z","timestamp":1738739522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho\u2010tau Round Robin study"],"prefix":"10.1002","volume":"21","author":[{"given":"Nicholas J.","family":"Ashton","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"King's College London Institute of Psychiatry Psychology and Neuroscience Maurice Wohl Clinical Neuroscience Institute London UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust London UK"},{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-5721","authenticated-orcid":false,"given":"Ashvini","family":"Keshavan","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Queen Square Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner S.","family":"Brum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Graduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Andreasson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience & Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Droescher","sequence":"additional","affiliation":[{"name":"Neuroscience Research AbbVie Deutschland GmbH & Co. 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