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Plasma amyloid beta (A\u03b2) 42\/40, four phosphorylated tau (p\u2010tau) epitopes, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) levels were measured using immunoassays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>NfL demonstrated fair to excellent accuracy in differentiating non\u2010ACS from CU groups (area under the curve [AUC], 0.79 to 0.94). p\u2010tau217 had the highest accuracy for identifying A\u03b2 (AUC 0.94) and tau positron emission tomography status (AUC 0.91). In the ACS group, p\u2010tau217 was the strongest predictor of cognitive decline (p\u00a0&lt;\u00a0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>NfL may serve as a useful screening tool, while p\u2010tau217 is particularly valuable for confirming AD pathology and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma NfL could screen for cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>p\u2010tau217 reliably detects AD pathology, regardless of diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>p\u2010tau217 and GFAP predict prognosis in ACS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Each plasma biomarker plays a distinct role in stepwise AD diagnostics.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14526","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:00:15Z","timestamp":1738738815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker\u2010guided diagnostics"],"prefix":"10.1002","volume":"21","author":[{"given":"Hyemin","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg G\u00f6teborg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital G\u00f6teborg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology, Queen Square London UK"},{"name":"UK Dementia Research Institute at UCL London UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay Hong Kong P.R. 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