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We used tiagabine, a gamma\u2010aminobutyric acid (GABA) re\u2010uptake inhibitor, as a pharmacological probe to assess the role of GABA during motor\u2010related beta power changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Task impairments were associated with diminished movement\u2010related beta power. Tiagabine facilitated partial recovery of behavioral impairments and neurophysiology, moderated by executive function, such that the greatest improvements were seen in those with higher cognitive scores. The right prefrontal cortex was revealed as a key site of drug interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Behavioral and neurophysiological deficits can be mitigated by enhancement of GABAergic neurotransmission. Clinical trials are warranted to test for enduring clinical benefits from this restorative\u2010psychopharmacology strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Event\u2010related beta power changes during movement can be altered by the GABA reuptake inhibitor, tiagabine.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>In people with behavioral\u2010variant frontotemporal dementia and progressive supranuclear palsy, tiagabine enhanced beta modulation and concurrently improved task performance, dependent on baseline cognition, and diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The effects of the drug suggest a GABA\u2010dependent beta\u2010related mechanism that underlies adaptive motor control.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Restoring selective deficits in neurotransmission is a potential means to improve behavioral symptoms in patients with dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14531","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:21:17Z","timestamp":1739942477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration"],"prefix":"10.1002","volume":"21","author":[{"given":"Laura 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