{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:41Z","timestamp":1790270801346,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias. This perspective proposes repurposing ADNI to address emerging research and healthcare challenges. The focus would shift toward early detection of cognitive impairment, discovering new interventions, evaluating non\u2010pharmacological treatments, adopting a public health approach, and enrolling a diverse international cohort. Key elements of this new model include emphasizing vascular\u2010metabolic factors, leveraging biomarkers, and enhancing computational capabilities. By reimagining ADNI's mission and framework, the initiative may be better poised to tackle the evolving complexities of dementia research and improve patient outcomes through a more comprehensive, multidisciplinary approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>ADNI should be repurposed for early detection and intervention in cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This would emphasize vascular\u2010metabolic factors and biomarkers in dementia research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>It advocates for non\u2010pharmacological evaluations and a public health approach.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>It promotes international cohort studies and enhanced computational capacity.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14534","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T06:52:33Z","timestamp":1741589553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perspective: Emerging challenges for a future ADNI"],"prefix":"10.1002","volume":"21","author":[{"given":"Zaven","family":"Khachaturian","sequence":"first","affiliation":[{"name":"Campaign to Prevent Alzheimer Disease  Potomac Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Alzheimer's Association Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara S.","family":"Khachaturian","sequence":"additional","affiliation":[{"name":"Brain Watch Coalition  Potomac Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.08.005"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S346"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14228"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.04.002"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14256"},{"key":"e_1_2_4_9_1","unstructured":"Personal communications with Mike Weiner Neil Buckholts Peter Snyder Bill Potter and Leon Thal [deceased]."},{"key":"e_1_2_4_10_1","unstructured":"KhachaturianZS.\u2018Oral history of the National Institute on Aging [NIA] 1976\u20101995\u2019\u2014History of Medicine & Stetten Museum National Library of Medicine [NLM] National Institutes of Health [NIH].https:\/\/history.nih.gov\/display\/history\/Khachaturian%2C+Zaven+2022"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.04.379"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2015.06.001"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774508089458"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12633"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.10.002"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.001"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.003"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12772"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880\u2010024\u201001224\u20105"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000588\u20104"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13157"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.14534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:40:08Z","timestamp":1789558808000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/alz.14534"],"URL":"https:\/\/doi.org\/10.1002\/alz.14534","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14534"}}