{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:02:00Z","timestamp":1793174520795,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n With the advancement of disease\u2010modifying therapies for Alzheimer's disease (AD), validating plasma biomarkers against cerebrospinal fluid (CSF) and positron emission tomography (PET) standards is crucial in both research and real\u2010world settings.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We measured plasma phosphorylated tau (p\u2010tau)217, p\u2010tau181, amyloid beta (A\u03b2)1\u201040, A\u03b21\u201042, and neurofilament light chain in research and real\u2010world cohorts. Participants were categorized by brain amyloid status using US Food and Drug Administration\/European Medicines Agency\u2013approved CSF or PET methods.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Plasma p\u2010tau217 and p\u2010tau217\/A\u03b21\u201042 demonstrated superior accuracy in detecting brain amyloid pathologies, with area under the curve from 0.94 to 0.97 in all cohorts. Specificity was lower in the real\u2010world cohort but improved significantly by integrating demographic and clinical factors, aligning performance with research cohorts. Additionally, plasma biomarkers exhibited strong correlations with their CSF counterparts and PET standardized uptake value ratios, with significant associations in amyloid\u2010positive participants.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Plasma p\u2010tau217 and p\u2010tau217\/A\u03b21\u201042 are effective diagnostic tools. However, patient demographics, apolipoprotein E \u03b54 status, and cognitive condition must be considered to improve specificity in the clinical practice.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Plasma phosphorylated tau (p\u2010tau)217 and p\u2010tau217\/amyloid beta (A\u03b2)1\u201042 demonstrated exceptional accuracy (area under the curve: 0.94\u20130.97) in detecting brain amyloid pathologies across both research (Southern China Aging Brain Initiative [SCABI]\u20101, SCABI\u20102) and real\u2010world clinical practice (RCP) cohorts.<\/jats:p>\n <\/jats:list-item>\n \n Incorporating patient\u2010specific factors (sex, age, apolipoprotein E \u03b54, cognitive status) improved diagnostic specificity in the clinical RCP cohort, aligning its performance with that of research cohorts.<\/jats:p>\n <\/jats:list-item>\n \n Plasma biomarkers, particularly p\u2010tau217 and their ratios, showed robust correlations with cerebrospinal fluid biomarkers and positron emission tomography amyloid standardized uptake value ratios, underscoring their value as non\u2010invasive diagnostic alternatives.<\/jats:p>\n <\/jats:list-item>\n \n Plasma p\u2010tau217 and p\u2010tau217\/A\u03b21\u201042 proved highly effective in diagnosing amyloid burden, offering a practical solution to bridge research advancements with real\u2010world clinical practice.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.14536","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:00:18Z","timestamp":1738220418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Plasma p\u2010tau217 and p\u2010tau217\/A\u03b21\u201042 are effective biomarkers for identifying CSF\u2010 and PET imaging\u2010diagnosed Alzheimer's disease: Insights for research and clinical 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