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Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We assessed the prognostic accuracy of plasma p\u2010tau217 in predicting the progression to mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals over a mean follow\u2010up of 5.65 years after plasma collection (range 1.01\u201310.47).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We included 215 participants from the PREVENT\u2212AD cohort with plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      and p\u2010tau217, 159 with cerebrospinal fluid (CSF) A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      and p\u2010tau217, and 155 with\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010NAV4694 and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010flortaucipir PET scans. MCI progression was determined by multidisciplinary consensus among memory experts blind to biomarker and genetic information.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cox proportional hazard models indicated a greater progression rate in A+T+\n                      <jats:sub>plasma<\/jats:sub>\n                      and A\u2212T+\n                      <jats:sub>plasma<\/jats:sub>\n                      compared to A\u2212T\u2212\n                      <jats:sub>plasma<\/jats:sub>\n                      individuals (HR\u00a0=\u00a07.81 [95% CI\u00a0=\u00a03.92 to 15.59] and HR\u00a0=\u00a04.25 [1.60\u201311.31] respectively). Similar results were found with CSF (HR\u00a0=\u00a03.63 [1.72\u20137.70]) and PET (HR\u00a0=\u00a09.30 [3.67\u201323.55]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 is a prognostic marker for identifying individuals who will develop cognitive impairment within ten years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Elevated plasma p\u2010tau217 levels in CU individuals indicate future clinical progression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Adding plasma A\u03b2\n                            <jats:sub>42\/40<\/jats:sub>\n                            status to p\u2010tau markers did not improve the prediction to MCI.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>All individuals with abnormal tau PET measured in a temporal meta\u2010ROI progressed to MCI.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14537","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T02:51:43Z","timestamp":1741575103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Plasma p\u2010tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10\u2010year window"],"prefix":"10.1002","volume":"21","author":[{"given":"Yara","family":"Yakoub","sequence":"first","affiliation":[{"name":"Douglas Mental Health University Institute Centre for Studies on the Prevention of Alzheimer's Disease (StoP\u2010AD)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gonzalez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital  Stavanger Norway"},{"name":"King's College London Institute of Psychiatry, Psychology &amp; 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