{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:01:48Z","timestamp":1791900108608,"version":"4.3.4"},"reference-count":277,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471450"],"award-info":[{"award-number":["82471450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Alzheimer's disease (AD) is a degenerative disease characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence and progression of AD pathology has been well documented. Poor nutritional status accelerates AD progress by potentially aggravating amyloid beta (A\u03b2) and tau deposition, exacerbating oxidative stress response, modulating the microbiota\u2013gut\u2013brain axis, and disrupting blood\u2013brain barrier function. The advanced stage of AD tends to lead to malnutrition due to cognitive impairments, sensory dysfunctions, brain atrophy, and behavioral and psychological symptoms of dementia (BPSD). This, in turn, produces a vicious cycle between malnutrition and AD. This review discusses how nutritional factors and AD deteriorate each other from the early stage of AD to the terminal stages of AD, focusing on the potential of different levels of nutritional factors, ranging from micronutrients to diet patterns. This review provides novel insights into reducing the risk of AD, delaying its progression, and improving prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Two\u2010fifths of Alzheimer's disease (AD) cases worldwide have been attributed to potentially modifiable risk factors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Up to \u224826% of community\u2010dwelling patients with AD are malnourished, compared to 7%\u223c76% of institutionalized patients.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Undernutrition effects the onset, progression, and prognosis of AD through multiple mechanisms.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Various levels of nutritional supports were confirmed to be protective factors for AD via specific mechanisms.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14547","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:24:01Z","timestamp":1737962641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nutrition: A non\u2010negligible factor in the pathogenesis and treatment of Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Boye","family":"Wen","sequence":"first","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Han","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Integrated Traditional Chinese and Western Medicine Changchun University of Chinese Medicine Jingyue National High\u2010tech Industrial Development Zone  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxian","family":"Sun","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidi","family":"Shan","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heya","family":"Luan","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Integrated Traditional Chinese and Western Medicine Changchun University of Chinese Medicine Jingyue National High\u2010tech Industrial Development Zone  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruina","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Beihang University  Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Integrated Traditional Chinese and Western Medicine Changchun University of Chinese Medicine Jingyue National High\u2010tech Industrial Development Zone  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runqi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Beihang University  Haidian District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuqiao","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  Xicheng District Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirong","family":"Lv","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital Capital Medical University National Clinical Research Center for Geriatric Diseases  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