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Higher baseline NT1\u2010tau levels predicted greater tau PET, with 2\u2010 to 10\u2010year intervals and faster longitudinal A\u03b2 PET increases, AD\u2010typical neurodegeneration, and cognitive decline. Plasma NT1\u2010tau showed negative correlations with baseline regional brain volume and thickness, superior to plasma brain\u2010derived tau (BD\u2010tau) and neurofilament light (NfL) in A\u03b2\u2010positive participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study suggests that plasma NT1\u2010tau is an A\u03b2\u2010dependent biomarker and outperforms BD\u2010tau and NfL in detecting cross\u2010sectional neurodegeneration in the AD continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma N\u2010terminal tau (NT1\u2010tau) was specifically increased in the A+\/T+ stage.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma NT1\u2010tau was positively associated with greater amyloid beta (A\u03b2) and tau PET (positron emission tomography) accumulations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher plasma NT1\u2010tau predicted greater tau burden and faster A\u03b2 increases.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma NT1\u2010tau was more related to neurodegeneration than plasma brain\u2010derived tau (BD\u2010tau) and neurofilament light (NfL).<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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