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understood, particularly in Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      RNA\u2010sequencing was carried out on blood samples from 248 participants in the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) and weighted gene co\u2010expression network analysis. Findings were replicated in an independent Korean cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0275).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      DGE analysis identified 18 and 88 dysregulated genes in EOAD and LOAD, respectively. Network analysis identified a LOAD\u2010associated module showing a significant enrichment in pathways related to mitophagy, 5\u2032 adenosine monophosphate\u2010activated protein kinase signaling, and ubiquitin\u2010mediated proteolysis. In the replication cohort, downregulation of\n                      <jats:italic>SMOX<\/jats:italic>\n                      and\n                      <jats:italic>PLVAP<\/jats:italic>\n                      in LOAD was replicated, and the LOAD\u2010associated module was highly preserved. In addition,\n                      <jats:italic>SMOX<\/jats:italic>\n                      and\n                      <jats:italic>PLVAP<\/jats:italic>\n                      were associated with brain amyloid beta deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest distinct molecular signatures for EOAD and LOAD in a Korean population, providing deeper understanding of their diagnostic potential and molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Analysis identified 18 and 88 dysregulated genes in early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset Alzheimer's disease (LOAD), respectively.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Expression levels of\n                            <jats:italic>SMOX<\/jats:italic>\n                            and\n                            <jats:italic>PLVAP<\/jats:italic>\n                            were downregulated in LOAD.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Expression levels of\n                            <jats:italic>SMOX<\/jats:italic>\n                            and\n                            <jats:italic>PLVAP<\/jats:italic>\n                            were associated with brain amyloid beta deposition.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Pathways including mitophagy and 5\u2032 adenosine monophosphate\u2010activated protein kinase signaling were enriched in a LOAD module.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A LOAD module was highly preserved across two independent cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14563","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T04:05:01Z","timestamp":1739333101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptome analysis of early\u2010 and late\u2010onset Alzheimer's disease in Korean 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