{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:50:44Z","timestamp":1790484644458,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C\u2010047"],"award-info":[{"award-number":["V113C\u2010047"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C\u2010079"],"award-info":[{"award-number":["V114C\u2010079"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma phosphorylated tau (p\u2010tau) biomarkers have improved Alzheimer's disease (AD) diagnosis, but data from diverse Asian populations are limited. This study evaluated plasma p\u2010tau217 and p\u2010tau181 levels in Korean and Taiwanese populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      All participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0270) underwent amyloid positron emission tomography (PET) and blood tests. Plasma p\u2010tau model\u2010derived probabilities of amyloid PET positivity (amyloid beta [A\u03b2]+) classified participants into low\u2010, intermediate\u2010, or high\u2010risk groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In both cohorts, plasma p\u2010tau217 outperformed p\u2010tau181, especially in cognitively unimpaired participants (area under the curve\u00a0=\u00a00.921 [p\u2010tau217] vs. 0.769 [p\u2010tau181],\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>difference\u00a0<\/jats:sub>\n                      =\u00a00.022). Including apolipoprotein E status and glial fibrillary acidic protein improved model fit. The negative predictive value of the low\u2010risk group and positive predictive value of the high\u2010risk group were 97.5% and 86.0%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 and p\u2010tau181 effectively predict A\u03b2+ among culturally different Asian populations. P\u2010tau217 performed better, especially in the early stages of AD. Plasma p\u2010tau217\u2013based models reduced intermediate\u2010risk classifications, suggesting fewer amyloid PET scans needed to confirm the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The efficacy of plasma phosphorylated tau (p\u2010tau)217 and p\u2010tau181 was analyzed in two Asian populations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 performs better in predicting amyloid positron emission tomography positivity, especially in cognitively unimpaired subjects.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Adding apolipoprotein E and glial fibrillary acidic protein to p\u2010tau improved model accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The models from each cohort were confirmed in the other cohort.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau\u2013based risk stratification may reduce the need for confirmatory tests.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14565","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T04:14:08Z","timestamp":1738124048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cross\u2010cultural validation of plasma p\u2010tau217 and p\u2010tau181 as precision biomarkers for amyloid PET positivity: An East Asian study in Taiwan and Korea"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-5516","authenticated-orcid":false,"given":"Yung\u2010Shuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Brain Research Center National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2005-0983","authenticated-orcid":false,"given":"Hyuk Sung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-4539","authenticated-orcid":false,"given":"Wei\u2010Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Brain Research Center National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Neurological Institute Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-6956","authenticated-orcid":false,"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology Ewha Woman's University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-5761","authenticated-orcid":false,"given":"Seong\u2010Ho","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University Guri Hospital Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3351","authenticated-orcid":false,"given":"Jong\u2010Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Brain Research Center National Yang Ming Chiao Tung University  Taipei 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