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Using %p\u2010tau217 or the APS2 in a theoretical AD trial screening scenario reduced amyloid positron emission tomography imaging costs up to 41% or 45%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These findings suggest that C\n                      <jats:sub>2<\/jats:sub>\n                      N Diagnostics\u2019 MS\u2010based plasma biomarkers can detect brain amyloid and tau with high accuracy prior to dementia and could aid in identifying candidates for clinical trials or therapeutic intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            C\n                            <jats:sub>2<\/jats:sub>\n                            N plasma biomarkers differentiated Alzheimer's disease proteinopathy status prior to dementia.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Plasma %phosphorylated tau (p\u2010tau)217 and the C\n                            <jats:sub>2<\/jats:sub>\n                            N Diagnostics PrecivityAD2 (APS2) were concordant with amyloid and tau positron emission tomography status.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma %p\u2010tau217 and the APS2 were associated with preclinical cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n             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