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Measurements are acquired at rest and during orthostatic challenges, hyperventilation, and carbon dioxide inhalation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The primary outcomes are baroreflex sensitivity and cerebral autoregulation. Secondary outcomes include aortic, carotid, and cerebral hemodynamics and various measures of autonomic function and vascular structure and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>POINTER\u2010NV will provide critical insight into neurovascular mechanisms that may change with intensive lifestyle modification and promote improvements in cognition and overall brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This study takes advantage of U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) to address key gaps in the field.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>POINTER Neurovascular (POINTER\u2010NV) will provide insight into neurovascular mechanisms underlying dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>POINTER\u2010NV may help shed light on modifiable vascular contributions to dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14574","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:31:44Z","timestamp":1741728704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The U.S. POINTER neurovascular ancillary study: Study design and methods"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-758X","authenticated-orcid":false,"given":"Tina E.","family":"Brinkley","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn R.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering Inc.  Norwood Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Tegeler","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest University School of Medicine, Medical Center Blvd  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Sarwal","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest University School of Medicine, Medical Center Blvd  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest University School of Medicine, Medical Center Blvd  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Internal Medicine Section on Cardiovascular Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Social Sciences and Health Policy Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Espeland","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Division of Medical and Scientific Relations Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen A.","family":"Claassen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Radboudumc Alzheimer Center Donders Institute for Brain Cognition and Behaviour Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margie 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