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Here, we developed machine learning models, the Florey CAA Score (FCAAS), to predict CAA severity (none\/mild\/moderate\/severe).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Building on an auto\u2010score\u2010ordinal algorithm, the FCAAS models were developed and validated using data collected by three cohort studies of aging and dementia. The developed FCAAS models were digitized as a web\u2010based tool. A pilot trial was conducted using this web\u2010based tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The FCAAS\u20104 achieved a mean area under the receiver operating characteristic curve (AUC\u2010ROC) of 0.74 (95% confidence interval: 0.71\u20130.77) and a Harrell generalized c\u2010index of 0.72 (0.70\u20130.75). Pilot trial results obtained a mean AUC\u2010ROC of 0.82 (0.71\u20130.85) and Harrell generalized c\u2010index 0.79 (0.73\u20130.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The FCAAS models demonstrate a promising performance in predicting CAA severity. This framework holds the potential for predicting development of amyloid\u2010related imaging abnormalities (ARIAs), given the CAA\u2013ARIAs link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            The severity of cerebral amyloid angiopathy (CAA) can only be determined\n                            <jats:italic>post mortem<\/jats:italic>\n                            .\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A web tool, the Florey CAA Score (FCAAS), was developed to predict CAA severity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The FCAAS holds the potential to be used for CAA risk stratification in clinics.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CAA is linked to increased risk of amyloid\u2010related imaging abnormalities (ARIAs).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The framework used by FCAAS can possibly be adapted to predict ARIAs risk.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14583","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:40:14Z","timestamp":1741758014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity"],"prefix":"10.1002","volume":"21","author":[{"given":"Chenyin","family":"Chu","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Ma","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental 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