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Cholinergic loss is linked to cognitive decline in these conditions, but its trajectory remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a cohort of 92 iRBD participants with baseline MRI, cholinergic basal forebrain (cBF) volume was measured, with longitudinal changes analyzed in 49 with\u00a0follow\u2010up scans. Cross\u2010sectional neuropsychological associations were examined across a broader RBD\u2013LBD continuum, including the iRBD cohort plus 65 PD and 15 DLB patients with probable RBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      cBF volume declined at comparable rates in iRBD\u2010to\u2010PD and iRBD\u2010to\u2010DLB converters, but atrophy was more severe at DLB phenoconversion. cBF atrophy correlated with attention, executive, and memory deficits. In iRBD, baseline cBF\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score &lt; \u22121.0 predicted dementia (hazard ratio =\u00a09.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>cBF degeneration evolves from the prodromal iRBD stage of LBDs and\u00a0predicts dementia, highlighting a window for cholinergic\u2010targeted intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Basal forebrain links to attention, executive function, and memory in the RBD continuum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Basal forebrain atrophy progresses at similar rates in prodromal PD and prodromal DLB.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>At phenoconversion, basal forebrain atrophy is greater in DLB than in PD converters.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Basal forebrain atrophy strongly predicts future dementia in iRBD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Executive dysfunction predicts faster basal forebrain degeneration in iRBD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14584","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T10:04:41Z","timestamp":1740218681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cholinergic degeneration and early cognitive signs in prodromal Lewy body dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-7348","authenticated-orcid":false,"given":"Kyung Ah","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Dongjak\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Dongjak\u2010gu Seoul Republic of Korea"},{"name":"Institute of Radiation Medicine Medical Research Center Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Dongjak\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Dongjak\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung 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