{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:53:37Z","timestamp":1793318017954,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2007912"],"award-info":[{"award-number":["GNT2007912"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2022203"],"award-info":[{"award-number":["GNT2022203"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["23AARF\u20101020292"],"award-info":[{"award-number":["23AARF\u20101020292"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) increases the risk of amyloid\u2010related imaging abnormalities in Alzheimer's disease (AD) patients receiving anti\u2010amyloid\u2010beta therapies, emphasizing the need to identify its risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Data were collected from three cohort studies, and a machine learning model was developed to predict CAA occurrence using the selected risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The AD neuropathologic changes (ADNC)\u2010CAA association was significantly positive in the cross\u2010sectional analysis. When stratified by selected risk factors, this association was generally stronger among females, smokers, people with a history of stroke\/memory complaints, apolipoprotein E (APOE)\u2010\u03b54 carriers, and those without diabetes\/heart conditions. In the longitudinal analysis of the association between potential risk factors and CAA, a higher risk of CAA was observed among males, older individuals, smokers, people with diabetes\/heart conditions, lower Mini\u2010Mental State Examination (MMSE) scores, and APOE\u2010\u03b54 carriers compared to their respective reference groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our study identified risk factors for cerebral amyloid angiopathy, informing potential prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>ADNC were significantly positively associated with the risk of CAA.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The ADNC\u2010CAA association was generally stronger among females, smokers, people with a history of stroke\/memory complaints, APOE\u2010\u03b54 carriers, and those without diabetes or heart conditions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Longitudinally, higher CAA risk was observed among males, older individuals, smokers, people with diabetes\/heart conditions\/lower MMSE scores, and APOE\u2010\u03b54 carriers compared to their reference groups.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14602","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:07:41Z","timestamp":1741712861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring epidemiological risk factors for cerebral amyloid angiopathy: Considerations for monoclonal antibody therapy in people with Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Liwei","family":"Ma","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Liem Hieu","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Aged Care Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine Austin Health The University of Melbourne  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanka","family":"Amadoru","sequence":"additional","affiliation":[{"name":"Department of Aged Care Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine Austin Health The University of Melbourne  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wrigley","sequence":"additional","affiliation":[{"name":"Department of Aged Care Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Aged Care Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine Austin Health The University of Melbourne  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Goudey","sequence":"additional","affiliation":[{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"},{"name":"The ARC Training Centre in Cognitive Computing for Medical Technologies The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Jin","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-3333","authenticated-orcid":false,"given":"Yijun","family":"Pan","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Parkville Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Cerebral Amyloid Angiopathy","author":"Kuhn J","year":"2024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.1.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12366"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00208-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.22.28461"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad188"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00637-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70015-7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.08.008"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040823"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179939"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322627"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0531-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24388"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030226"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595082"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200182"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.623462"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws234"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002175"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg074"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04797.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13704"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024149"},{"key":"e_1_2_10_30_1","volume-title":"Neuroanatomy, Frontal Cortex","author":"El\u2010Baba RM","year":"2024"},{"key":"e_1_2_10_31_1","volume-title":"Neuroanatomy, Temporal Lobe","author":"Patel A","year":"2024"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136136"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.1004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.00038"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13352"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201664"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037009"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420954811"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2023.22.3.87"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000065200.93070.32"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000100165.36466.95"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102515"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh253"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172915.71933.00"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.098"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14583"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.14602","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.14602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:17:08Z","timestamp":1789553828000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/alz.14602"],"URL":"https:\/\/doi.org\/10.1002\/alz.14602","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14602"}}