{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:08:23Z","timestamp":1789560503277,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Early symptoms in young onset Alzheimer's disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population\u2010based study aimed to map adverse occupational events preceding YOAD diagnosis as potential prodromal signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a register\u2010based, incidence density matched nested case\u2010control study, we examined unemployment and long\u2010term sick leave among individuals diagnosed with YOAD in Danish memory clinics between 2016 and 2022 compared to controls over a 13\u2010year period. Conditional logistic regression produced incidence rate ratios (IRRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The study included 2434 cases and 12,170 controls. YOAD patients had higher rates of adverse occupational events, particularly long\u2010term sick leave, starting from 8 years before diagnosis (IRR 1.40, 95% confidence interval [CI] 1.07\u20131.84) and increasing to an IRR of 29.59 (95% CI 18.97\u201346.13) in the year before diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Adverse occupational events may serve as warning signs of YOAD. Timely diagnosis could facilitate restructuring the remaining working life to accommodate cognitive deficits or in seeking a disability pension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>HIGHLIGHTS<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This is a retrospective, nested case\u2010control study of young onset Alzheimer's disease (YOAD).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Unemployment rates rise significantly 5 years before the YOAD diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Long\u2010term sick leave rates rise significantly 8 years before the YOAD diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This emphasizes the importance of occupational history in the timely diagnosis of YOAD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings suggest the need for earlier YOAD diagnosis for work\u2013life management.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14607","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T04:20:39Z","timestamp":1740543639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patterns of sick leave and unemployment prior to a diagnosis of young onset Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Line","family":"Damsgaard","sequence":"first","affiliation":[{"name":"Danish Dementia Research Centre, Section 8008, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pedersen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Laursen","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010based Research, Department of Economics and Business Economics Aarhus BSS, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Nabe\u2010Nielsen","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stevie","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Jensen\u2010Dahm","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Section 8008, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Section 8008, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Janbek","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre, Section 8008, Department of Neurology Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70159\u20109"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.International Classification of Diseases (ICD\u201010) 2019version. 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