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Participants consented to undergoing annual neuropsychological assessments, allowing researchers access to convent archives and medical records and\n                      <jats:italic>post mortem<\/jats:italic>\n                      brain donation. This study investigated the associations between epidemiological factors, cognitive function, and brain pathology. By examining published literature that reports on or utilizes Nun Study data, we provide an overview of its methodology and key findings, emphasizing its significant contributions to understanding cognitive impairment and related neuropathologies. Seminal findings on early\u2010life factors affecting cognitive health, clinicopathological correlations, and apparent resistance and resilience to neuropathology are discussed. Decades of Nun Study research have made critical contributions to our understanding of Alzheimer's disease and related dementias and highlight continuing objectives for future research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The uniform lifestyles of participants minimized potential confounds of the study.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Early\u2010life cognitive ability influenced late\u2010life cognitive outcomes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Some participants with AD pathology did not exhibit dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neuropathological comorbidities were common and increased the risk of dementia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14626","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:35:14Z","timestamp":1741732514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Nun Study: Insights from 30 years of aging and dementia research"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1913-3992","authenticated-orcid":false,"given":"Kyra M.","family":"Clarke","sequence":"first","affiliation":[{"name":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health 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