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In this study we evaluate the association of plasma Alzheimer's disease (AD) biomarkers with amyloid PET progression among initially amyloid PET negative (A\u2212) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included 290 A\u2212, cognitively unimpaired Mayo Clinic Study of Aging participants. We estimated the association of each baseline plasma biomarker with progression from A\u2212 to A+ and with rate of amyloid PET change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Interquartile range differences in amyloid beta 42\/40, percent phosphorylated tau 217 (%p\u2010tau217), and Amyloid Probability Score 2 were associated with 1.29 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.09), 1.38 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and 1.20 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.05) increases, respectively, in the hazard of progression from A\u2212 to A+ and 0.27 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.16), 0.50 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007), and 0.28 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.15) Centiloid\/year increases, respectively, in annual rate of amyloid PET change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma %p\u2010tau217 may be a useful screening tool to enrich for participants with increased likelihood of progressing from normal to abnormal amyloid PET in a primary prevention trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma phosphorylated tau 217 was associated with amyloid positron emission tomography progression, negative to positive.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The associations were weaker for amyloid beta 42\/40 and Amyloid Probability Score\u00a02.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Age and apolipoprotein E \u03b54 carriership were also important predictors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These markers may be useful for enrichment of a primary prevention trial.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.14629","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:34:59Z","timestamp":1740540899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET"],"prefix":"10.1002","volume":"21","author":[{"given":"Petrice M.","family":"Cogswell","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Wiste","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester 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