{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:32:52Z","timestamp":1791844372295,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Cerebral amyloid angiopathy (CAA) is characterized by the deposition of beta\u2010amyloid (A\u03b2) in small vessels leading to hemorrhagic stroke and dementia. This study examined whether plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , phosphorylated\u2010tau (p\u2010tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) differ in CAA and their potential to discriminate Boston Criteria 2.0 probable CAA from healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , p\u2010tau\u2010181, NfL, and GFAP were quantified using single molecule array (Simoa) and A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      was also independently quantified using immunoprecipitation liquid chromatography mass\u2010spectrometry (IPMS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five participants with CAA and 47 healthy controls had available plasma. A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratios were significantly lower in CAA than healthy controls. While p\u2010tau\u2010181 and NfL were elevated in CAA, GFAP was similar. A combination of A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      (Simoa), p\u2010tau\u2010181, and NfL resulted in an area under the curve of 0.90 (95% confidence interval: 0.80, 0.95).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , p\u2010tau\u2010181, and NfL differ in those with CAA and together can discriminate CAA from healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Participants with CAA had reduced plasma A\u03b2\n                            <jats:sub>42\/40<\/jats:sub>\n                            ratios compared to controls.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau\u2010181 and NfL concentrations are elevated in CAA compared to controls.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma GFAP was similar in CAA and controls.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Together, plasma A\u03b2\n                            <jats:sub>42\/40<\/jats:sub>\n                            , p\u2010tau\u2010181, and NfL had excellent discriminability for CAA.\n                          <\/jats:p>\n                        <\/jats:list-item>\n        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